Rate Limiting Enzymes

• Phosphofructokinase-1 Glycolysis
• Pyruvate dehydrogenase complex          Pyruvate Metabolism
• Isocitrate dehydrogenase            TCA cycle
• Citrate synthase               Citric acid cycle
• Glycogen synthase          Glycogenesis
• Glycogen phosphorylase              Glycogenolysis
• Phosphoenolpyruvate carboxykinase     Gluconeogenesis
• Glucose 6 phosphat dehydrogenase       Hexose Monophosphate Shunt
• HMG-CoA reductase      Cholesterol synthesis
• HMG-CoA synthease     Ketone body formation
• Acetyl CoA carboxylase Fatty acid synthesis
• Carnitine acyl transferase [CPT-1]              oxidation of fatty acids
• Cytidyl transferase          Phospholipid synthesis
• 3 ketosphiganine synthase          Sphingolipid synthesis
• Phospholipase A2            Eicosanoid synthesis
• CSCC (27 desmolase)      Steroidogenesis
• Aminolevulinate synthase           Heme synthesis
• Active transport into bile ducts  Bilirubin metabolism
• Colesterol 7 hydroxylase            Bile acid synthesis
• Ribonucleotide reductase            DNA synthesis
• Glutamine Prp transferase          Purine synthesis
• Carbamoyl phosphate synthetase II        Pyrimidine synthesis
• Carbamoyl phosphate synthetase I         Urea cycle ( One=Urea)