Lipids

• Adrenoleukodystrophy: Underlying problem = defective long chain FA

• FA Oxidation : “OHOT”

Oxidation → 7 NADH → goes to ETC (3 ATP:1NADH)  = 21 ATP

Hydate

Oxidation → 7 FADH₂ → goes to ETC (2 ATP:1 FADH₂) = 14 ATP

Thiolysis → 8 Acetyl CoAs → goes to Kreb cycle (12 ATP: 1 Acetyl CoA) = 96 ATP

• #C / 2 = ATPs

TOTAL = 131 ATP

• HMG CoA Reductase is most active at 8:00 pm…Therefore, give Statin drugs at 8:00 pm!

• Odd chain FA are exception to the rule that FA cant be converted to Glucose.