- Adrenoleukodystrophy: Underlying problem = defective long chain FA
- FA Oxidation : “OHOT”
Oxidation → 7 NADH → goes to ETC (3
ATP:1NADH) = 21 ATP
Hydate
Oxidation → 7 FADH2 →
goes to ETC (2 ATP:1 FADH2) = 14 ATP
Thiolysis
→ 8 Acetyl CoAs → goes to Kreb cycle (12 ATP: 1 Acetyl CoA) =
96 ATP
- #C / 2 = ATPs
TOTAL = 131 ATP
- HMG CoA Reductase is most active at 8:00 pm…Therefore, give Statin drugs at 8:00 pm!
- Odd chain FA are exception to the rule that FA cant be converted to Glucose.
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