- 4 types of Glucose Transporters
GLUT 1 & 3 (Km:
1mM)
o Found
in most tissues → HIGH AFFINITY for Glucose
o Allow
for basal uptake
GLUT 2 (Km:
15mM)
o Found
in the LIVER & β Cells of PANCREAS → LOW AFFINITY
§ A
low affinity makes sure that glucose will bypass LIVER and go to the systemic
circulation to the necessary organs
GLUT 4 (Km:
5mM)
o Found
in MUSCLE & ADIPOSE TISSUE
o Insulin
regulated!!!
§ Makes
sure glucose gets INTO muscle and adipose tissue
o ↓
Insulin
§ Endocytosed
GLUT 4 transporters that are bound to cytoplasmic vesicles
o ↑
Insulin
§ Exocytosis
of GLUT 4, places them on membrane = Maximum uptake of glucose
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