Forensic Medicine

Showing posts with label Ophthalmology. Show all posts
Showing posts with label Ophthalmology. Show all posts

Tuesday, September 1, 2015

Ophthalmology Updates

·         Advances in LASIK. Recently many advances have been made in LASIK surgery. Some of the important advances are:
Customized (C) LASIK. C-LASIK is based on the wave front technology. This technique, in addition to spherical and cylindrical correction, also corrects the aberrations present in the eye and gives vision beyond 6/6 i.e., 6/5 or 6/4
Epi-(E) LASIK. In this technique instead of corneal stromal flap only the epithelial sheet is separated mechanically with the use of a customized device (Epiedge Epikeratome). Being an advanced surface ablation procedure, it is devoid of complications related to corneal stromal flap.
·         Recently, promising results are reported with adenine arabinoside (Ara-A) IN Rx of Epidemic Keratoconjunctivitis (EKC).
·         Recently VKC or Spring Cattarh is being labelled as 'Warm weather conjunctivitis'.
·         Topical cyclosporine (1%) drops have been recently reported to be effective in severe unresponsive cases of VKC.
·         Recently described treatment modality include topical nerve growth factor drops and amniotic membrane transplantation in Neuroparalytic keratitis.
·         Recently, lot of stress is being laid on the role of HLA in uveitis, since a number of diseases associated with uveitis occur much more frequently in persons with certain specific HLA-phenotype. A few examples of HLA-associated diseases with uveitis are as follows:
HLA-B27. Acute anterior uveitis associated with ankylosing spondylitis and also in Reiter’s syndrome.
HLA-B5: Uveitis in Behcet’s disease.
HLA-DR4 and DW15: Vogt Koyanagi Harada’s disease.
·         There is no specific treatment of CID (CYTOMEGALIC INCLUSION DISEASE). Recently treatment with intravenous dihydroxypropylmethyl guanine has been shown to cause regression in some cases.
·         Nerve fibre layer analyzer (NFLA) is a recently introduced device which helps in detecting the glaucomatous damage to the retinal nerve fibres before the appearance of actual visual field changes and/or optic disc changes.
·         Spindle cell theory proposed recently for ROP postulates the induction of retinal and vitreal neovascularization by spindle cell insult in a premature retina.
·         The following scheme for the pathogenesis of Graves’ ophthalmopathy has been recently proposed:
1.       Circulating T cells in patients with Graves’ disease directed against an antigen on thyroid follicular cells, recognize this antigen on orbital and pretibial fibroblasts (and perhaps extraocular myocytes). How these lymphocytes came to be directed against a self-antigen, escaping deletion by the immune system, is unknown.
2.       The T cells then infiltrate the orbit and pretibial skin. An interaction between the activated CD4 T cells and local fibroblasts results in the release of cytokines into the surrounding tissue – in particular, interferon-interleukin-1, and tumor necrosis factor.
3.       These or other cytokines then stimulate the expression of immunomodulatory proteins (the 72-kd heat-shock protein, intercellular adhesion molecules, and HLA-DR) in orbital fibroblasts, thus perpetuating the autoimmune response in the orbital connective tissue.
4.       Furthermore, particular cytokines (interferon-, interleukin-1, transforming growth factor, and insulin-like growth factor 1) stimulate glycosaminoglycan production in fibroblasts, proliferation of fibroblasts, or both, leading to the accumulation of glycosaminoglycans and oedema in the orbital connective tissue. In addition, thyrotropin-receptor or other antibodies may have direct biological effects on orbital fibroblasts or myocytes; alternatively, these antibodies may reflect the on going autoimmune process.
5.       The increase in connective-tissue volume and the fibrotic restriction of extraocular-muscle movement resulting from fibroblast stimulation lead to the clinical manifestations of ophthalmopathy. A similar process occurring in the pretibial skin results in the expansion of dermal connective tissue, which in turn leads to the nodular or diffuse skin thickening characteristic of pretibial dermopathy.

Saturday, May 23, 2015

Triads in Ophthalmology

·         BÁLINT'S SYNDROME  is loosely associated with a triad of visuospatial dysfunctions: simultanagnosia, optic ataxia, and ocular motor apraxia

·         BEHÇET'S DISEASE was initially described by Behçet in 1937 as a triad of oral ulcers, genital ulcers and hypopyon uveitis.

·         CEREBRAL WHIPPLE'S DISEASE includes a triad of somnolence, dementia and ophthalmoplegia.

·         CONE DEGENERATION includes the hallmark triad of progressive central acuity loss, color vision disturbances and photophobia.

·         CONGENITAL GLAUCOMA includes the commonly described triad of epiphora, blepharospasm and photophobia .

·         CONGENITAL RUBELLA RETINOPATHY includes the triad of cataracts, deafness and congenital heart disease which was first described by Gregg in 1941

·         CONGENITAL TOXOPLASMOSIS includes the classic triad of retinochoroiditis, hydrocephalus and intracranial calcifications although other signs such as fever, rash, hepatosplenomegaly, and seizures may occur if the infection is acquired earlier than the third trimester.

·         DE MORSIER'S SYNDROME, the congenital syndrome of septo-optic dysplasia includes the clinical triad of short stature, nystagmus and optic disc hypoplasia.

·         FECHTNER'S SYNDROME includes triad of nephritis, sensorineural hearing loss and eye abnormalities

·         GAUCHER DISEASE, classic Gaucher triad consists of trismus, strabismus, and opisthotonus.

·         HORNER'S SYNDROME includes classic triad of ptosis, miosis and ipsilateral anhidrosis of the face

·         INTRAOPERATIVE FLOPPY IRIS SYNDROME described by John Campbell and David F. Chang in 2005 which includes the triad by a flaccid iris stroma that undulates and billows in response to ordinary intraocular fluid currents ,a propensity for the floppy iris stroma to prolapse toward the phaco and side-port incisions, despite proper wound construction and progressive intraoperative pupil constriction despite standard preoperative pharmacologic measures designed to maximize dilation (topical cycloplegics, phenylephrine, and nonsteroidal anti-inflammatory medications).

·         KEARNS–SAYRE SYNDROME includes the triad of external ophthalmoplegia, pigmentary retinopathy and cardiac conduction block during the first or second decade of life

·         LAMBERT–EATON MYASTHENIC SYNDROME includes triad of muscle weakness, autonomic dysfunction and hyporeflexia

·         MILLER-FISHER SYNDROME consists of the triad of ataxia, ophthalmoplegia and areflexia .It is described as a variant of Guillain-Barré syndrome.

·         OCULAR ISCHEMIC SYNDROME includes the classic triad includes midperipheral dot hemorrhages, dilated retinal veins and iris neovascularization.

·         OCULAR TILT REACTION consists of the triad of skew deviation, cyclotorsion of both eyes and paradoxical head tilt, all to the same side—that of the lower eye

·         OPTIC NERVE SHEATH MENINGIOMA are characterized by the clinical triad of the presence of optociliary venous shunts on the disc, when accompanied by diffuse disc edema (eventually replaced slowly by pallor) and insidious visual loss

·         OSTEOGENESIS IMPERFECTA originally described late in the 18th century, osteogenesis imperfecta (Van der Hoeve's syndrome, brittle bone disease) was not well described as a clinical syndrome until 1918 by Van der Hoeve. The syndrome includes triad of brittle bones, blue scleras and deafness (otosclerosis) .

·         PHARYNGOCONJUNCTIVAL FEVER by Adenoviruses sometimes produces the classic triad of fever, pharyngitis and acute follicular conjunctivitis.

·         PIERRE ROBIN SYNDROME includes the diagnostic triad of micrognathia, glossoptosis and cleft palate.

·         PIGMENTARY GLAUCOMA includes the classic triad consists of corneal pigmentation (Krukenberg's spindle); slit-like, radial, midperipheral iris transillumination defects; and heavy accumulation of pigment in the trabecular meshwork.

·         PRESUMED OCULAR HISTOPLASMOSIS SYNDROME includes the triad: peripapillary atrophy, “punched-out” chorioretinal lesions and disciform macular scarring in young and middle-aged adults

·         REITER'S SYNDROME was originally described by the classic triad of arthritis, urethritis and conjunctivitis. In 1981, the American Rheumatism Association expanded this original set of criteria .

·         SCHWARTZ'S SYNDROME includes triad of rhegmatogenous retinal detachment, uveitis and glaucoma

·         SJÖGREN'S SYNDROME Sjögren's syndrome originally was described as a triad of dry eyes, dry mouth, and Arthritis (dry joints). It subsequently has become apparent that Sjögren's syndrome may coexist with a variety of other connective tissue diseases

·         SPASMUS NUTANS occurs in the first year of life and includes triad of pendular nystagmus, head nodding and torticollis.

·         STURGE-WEBER SYNDROME includes triad of port wine facial telangiectasis (nevus flammeus) in the distribution of the trigeminal nerve that respects the vertical midline, ipsilateral glaucoma(ipsilateral buphthalmos)and contralateral seizures caused by ipsilateral leptomeningeal hemangiomatosis.

·         UGH SYNDROME, an IOL-related inflammation which involves the triad of uveitis, glaucoma and hyphema. UGH syndrome occurred more frequently in the 1970s, when iris-fixed lenses were commonly used.
 

·         Triads …from Anatomy
The rod and cone terminals are organized as invaginating synapses, termed triads, each containing a single presynaptic ribbon, two lateral processes from horizontal cells, and a single central process from a bipolar cell. Each rod spherule contains a single triad; each cone pedicle contains several triads.

Ocular ADRs of Drugs

C.V.S. drugs
_ Digitalis: Disturbance of colour vision, scotomas
_ Quinidine: Optic neuritis (rare)
_ Thiazides: Xanthopsia (yellow vision), Myopia
_ Carbonic anhydrase inhibitors: Ocular hypotony, Transient myopia
_ Amiodarone: Corneal deposits
_ Oxprenolol: Photophobia, Ocular irritation

G.I.T. drugs
_ Anticholinergic agents: Risk of angle-closure glaucoma due to mydriasis, Blurring of vision due to cycloplegia (Occasional).

C.N.S. drugs
_ Barbiturates: Extraocular muscle palsies with diplopia, Ptosis, Cortical blindness
_ Chloral hydrate: Diplopia, Ptosis, Miosis
_ Phenothiazines: Deposits of pigment in conjunctiva, cornea, lens and retina, Oculogyric crisis
_ Amphetamines: Widening of palpebral fissure, Dilatation of pupil, Paralysis of ciliary muscle with loss of accommodation
_ Monoamine oxidase inhibitors: Nystagmus, Extraocular muscle palsies, Optic atrophy
_ Tricyclic agents: Pupillary dilatation (glaucoma risk), Cycloplegia
_ Phenytoin: Nystagmus, Diplopia, Ptosis, Slightblurring of vision (rare)
_ Neostigmine: Nystagmus, Miosis
_ Morphine: Miosis
_ Haloperidol: Capsular cataract
_ Lithium carbonate: Exophthalmos, Oculogyric crisis
_ Diazepam: Nystagmus.
Hormones
Female sex hormones
_ Retinal artery thrombosis
_ Retinal vein thrombosis
_ Papilloedema
_ Ocular palsies with diplopia
_ Nystagmus
_ Optic neuritis and atrophy
_ Retinal vasculitis
_ Scotomas
_ Migraine
_ Mydriasis
_ Cyloplegia
_ Macular oedema
Corticosteroids
_ Cataract (posterior subcapsular)
_ Local immune suppression causing susceptibility to viral (herpes simplex), bacterial and fungal infections
_ Steroid-induced glaucoma
Antibiotics
_ Chloramphenicol: Optic neuritis and optic atrophy
_ Streptomycin: Optic neuritis
_ Tetracycline: Pseudotumour cerebri, Transient myopia
Antimalarial
Chloroquine
_ Macular changes (Bull’s eye maculopathy)
_ Central scotomas
_ Pigmentary degeneration of the retina
_ Chloroquine keratopathy
_ Ocular palsies
_ Ptosis
_ Electroretinographic depression
Amoebicides
_ Diiodohydroxy quinoline: Subacute myelo optic neuropathy (SMON), optic atrophy
Chemotherapeutic agents
_ Sulfonamides: Stevens-Johnson syndrome
_ Ethambutol: Optic neuritis and atrophy
_ Isoniazid: Optic neuritis and optic atrophy
Heavy metals
_ Gold salts: Deposits in the cornea and conjunctiva
_ Lead: Optic atrophy, Papilloedema, Ocular palsies
Chelating agents
_ Penicillamine: Ocular pemphigoid, Ocular neuritis, Ocular myasthenia
Oral hypoglycemic agents
_ Chloropropamide: Transient change in refractive error, Diplopia, Stevens-Johnson syndrome
Vitamins
Vitamin A
_ Papilloedema
_ Retinal haemorrhages
_ Loss of eyebrows and eyelashes
_ Nystagmus
_ Diplopia and blurring of vision
Vitamin D
_ Band-shaped keratopathy
Antirheumatic agents
_ Salicylates: Nystagmus, Retinal haemorrhages, Cortical blindness (rare)
_ Indomethacin: Corneal deposits
_ Phenylbutazone: Retinal haemorrhages

Ophthalmology Facts from Previous Papers

·         Chorda Tympani Nerve passes between the internal jugular vein and internal carotid artery as it travels anteriorly.

·         The sytlomastoid foramen is found in the temporal bone between the mastoid process and the styloid.

·         The carotid canal is on the inferior surface of the petrous part of the temporal bone.

·         The jugular foramen is formed between the temporal and occipital bones.

·         The optic canal is situated in the sphenoid bone

·         The foramen ovale is found in the greater wing of the sphenoid

·         The pituitary fossa is part of the middle cranial fossa. It is formed by the body of the sphenoid bone. The dura mater forms its roof. The cavernous sinus is found on either side. It is bounded by the anterior and posterior clinoid processes.

·         The fifth cranial nerve provides sensation to the face except for a region around the angle of the mandible which is supplied by C2 and C3 in the form of the great auricular nerve.

·         Cataract does not impair the pupillary light reflex.

·         The infundibulum of pitutary connects to the tuber cinereum of hypothalamus.

·         Incongruous hemianopia occurs in lesion of the optic tract. Congruous hemianopia occurs if the lesion is in the optic radiation or the visual cortex.

·         Light adaptation takes about 5 minutes and dark adaptation about 20 minutes in the normal population. It is biphasic. The dark adaptation time is related to the time required to build up rhodopsin stores. Wearing red glasses can speed up dark adaptation because red light stimulate rods only minimally in the light.

·         In MS, ERG & EOG is normal but VEP is delayed..if both VEP & ERG are abnormal, it suggests that VEP is delayed secondarily to abnormal ERG.

·         Vogt white limbal girdle: Age related corneal degeneration.
Characterized by bilateral, narrow cresentic lines composed of chalky white deposits(present in Bowman’s membrane) in the interpalpebral fissure along the nasal& temporal limbus.
Type1: separated from limbus by clear interval
Type2: No clear zone in between

·         Mild blurring of central vision with drusen within Bruch membrane beneath RPE. Diagnosis – Macular degeneration.

·         Vit D deficiency asso with – Zonular cataract

·         Which does not maintain A-P stability of eyeball – Superior oblique
(AA AIIMS May 09 Q.170 : Answer given is – Suspensory ligament of eye ball)

Community Ophthalmology

·         WHO definition of blindness. In order to have comparable national and international statistics, the WHO in 1972 proposed a uniform criterion and defined blindness as, “Visual acuity of less than 3/60 (Snellen) or its equivalent”. In order to facilitate the screening of visual acuity by non-specialised persons, in the absence of appropriate vision charts, the WHO in 1979 added the “Inability to count fingers in day-light at a distance of 3 metres” to indicate vision less than 3/60 or its equivalent. Visual filed less than 10º, irrespective of the level of visual acuity in also labelled as blindness (WHO, 19774).
·         Other definitions of blindness in vogue are:
_ Economic blindness: vision in better eye <6/60 to 3/60
_ Social blindness: Vision in better eye <3/60 to 1/60
_ Legal blindness: Vision in better eye <1/60 to perception light
_ Total blindness: No light perception (PL -ve).

·         Vision 2020: The Right to Sight’,10 is a global initiative launched by WHO in Geneva on Feb. 18,1999 in a broad coalition with a ‘Task Force of International Non-Governmental Organisations (NGOs)’ to combat the gigantic problem of blindness in the world. Partners of Vision 2020: Right to Sight include:
I. World Health Organisation (WHO),
II. Task Force of International NGOs, which has following members:
_ International Agency for Prevention of Blindness (IAPB)
_ Christopher Blindness Mission (CBM)
_ Helen Keller International
_ ORBIS International
_ Sight Savers International
_ Al Noor Foundation
_ International Federation of Ophthalmological Societies
_ Lions Clubs International Foundation
_ Operation Eye Sight Universal
_ The Carter Centre

·         W.H.O. has organized an Alliance for Global Elimination of Trachoma by the year 2020 (GET 2020).
·         Vision for the future (VFTF): International Ophthalmology Strategic Plan to Preserve and Restore Vision11, launched in Feb 2001, is another global initiative (in addition to Vision 2020) for prevention of blindness. Implementation of this program is being done by International Council of Ophthalmology (ICO) by working closely with other international, supranational and national organizations. It is parallel to and complementary of ‘Vision 2020’. Care is being taken to avoid duplication.
Top priorties for action of this programme are:
  1. Enhancement of ophthalmology residency training around the world, particularly through definition of principles, guidelines and curricula.
  2. Development of model guidelines and recommendations for ophthalmic clinical care in critical disease areas.
  3. Dissemination of sample curricula for training of medical students and allied health personnel.
  4. Advocacy and support for ‘Vision 2020: Right to Sight’, particularly by encouraging national ophthalmologic societies to support the initiative and become involved.
  5. Helping national ophthalmologic societies develop more effective organizations.

·         Target diseases identified for intervention under ‘Vision 2020’ initiative in India include:
_ Cataract,
_ Childhood blindness,
_ Refractive errors and low vision,
_ Corneal blindness,
_ Diabetic retinopathy,
_ Glaucoma, and
_ Trachoma (focal)

·         Mid-Level Ophthalmic Personnel (MLOP). The term MLOP has been introduced to include all categories of paramedics who work full time in eye care. Broadly two streams of such personnels are envisaged:
  1. Hospital-based MLOP. These include ophthalmic nurses, ophthalmic technicians, optometrists, and orthoptists etc.
  2. Community-based MLOP include those with outreach/field functions such as primary eye care workers and ophthalmic assistants.

·         Presently two types of eye camps are held:
Comprehensive eye care camps with ‘Reach-out Approach’, and
Screening eye camps (Reach-in-Approach with comprehensive eye care). As mentioned earlier the recent emphasis is on the ‘Reach-in-Approach’.

Optics

·         Minimal angle of resolution of an eye with a 6/6 acuity: One degree of arc
·         An eye with 6/6 visual acuity read the 6/24 lines from 24 m away.
·         Snell's law of refraction: the incident and refracted rays and the normal to the surface at the point of incidence lie in the same plane and the ratio of the sine of the angle of incidence i to the sine of the angle of refraction r is a constant for any two media. This constant is called the relative index of refraction ie. sine i / sin r = refractive index.
·         Apex angle in degrees of a 10 dioptres prism made of glass: 10 degrees
·         The nodal point of a thin lens is at the intersection between the principle axis and the principle plane.
·         The refracting power of a cylindrical lens is at 90 degrees to the axis.
·         The image produced by a negative lens is virtual, erect & diminished.
·         A focimeter measures the BACK VERTEX POWER of a lens.
·         A decentration of 10 mm from the optical centre of a +5 dioptre lens produces a prismatic effect of  5 prism dioptres.
·         A X8 loupe has an equivalent power of 32  dioptres.
·         A lens of +10 dipotres fully correct an hyperopia and now the lens is moved forward 10mm, what is the new lens power needed to correct the hyperopia: +9D
Dn = Do/1-dDo
 where Dn = the new power
Do = the old lens power
d = difference in the location (in meters), -ve if it is moved forward and +ve if it is moved backward.
·         In trifocals the intermediate lens usually has half power over the distance correction.
·         The LTF stands for LUMINANCE TRANSMISSION when considering tints.
·         Relative spectacle magnification = Actual size corrected with spectacle / size seen by the emmetropic eye
·         Visible light contains wavelengths between 400 and 780nm. Ultraviolet A has wavelength of 315-400nm whereas ultraviolet C 200- 280nm. Thus in order of increasing wavelengths: ultraviolet C, ultraviolet B, ultraviolet A; visible light; infrared A, infrared B and infrared C. The lens is very efficient at absorbing ultraviolet than infrared light. The thermal burn in eclipse burn is caused by infrared light.

·         Red-green defect is seen in acquired optic nerve disease, cone dystrophy and Stargardt's disease.
Blue-yellow defects are seen in most retinal dystrophy, glaucoma and autosomal dominant optic neuropathy.

·         Farnsworth-Munsell hue 100 test contains 84 colour discs to be arranged in order of closest colour match with the reference colours at each end. The colours only differ in hue with same brightness and saturation. Ishihara test plates are mainly for congenital red-green colour defect. Wavy lines are used in Ishihara plates for illiterates or children. Lanthony New Colour Test can be used in children.

·         Illuminance and irradiance are terms used to refer to the amount of light arriving at a given point. Radiance refers to the amount of light leaving a certain point.

·         The refractive index of a human lens increases with age due to the development of cataract. In addition, the human lens does not have uniform refractive index being higher in the nucleus (1.400) than the cortex (1.380) in a non-cataractous lens.

·         The image formed by a prism is erect, virtual and deviated towards the apex.

·         Fresnel prisms reduce the weight of conventional prism and used widely in treating patients with strabismus. They are made up of a series of small prisms. The most common type are made up of polyvinyl chloride. They reduce the visual acuity mainly through chromatic aberrations. They are usually applied to the the back of patients' glasses.

·         Prentice rule: Prism dioptre = distance from the optic centre (cm) X dioptre power of the lens.
The induced prismatic effect is 1D.

·         The vergence power of a lens is affected by the vergence power of each surface, thickness of the lens and the medium on either side of the lens. The later explain why cornea has a stronger refractive power than lens in human eye although its refractive index is less. The wavelength of the light also affects the vergence power of the lens.

·         The first focal length has the same length as the second focal length only if the media on either side of the lens are the same. The first focal length of a convex lens is to the left of the lens whereas that of the concave lens is to the right of the lens.
By convention, the second focal length has a positive sign for convex lens and a negative sign for concave lens. As lenses are designated by their second focal lengths, a convex lens is also called a plus lens and a concave lens a negative lens.

·         The magnifying power is calculated to be M/4 where M is the power of the lens in dioptres.

·         The increasing prismatic effect of the more peripheral parts of a spherical lens is responsible for:
· spherical aberration
· ring scotoma
· jack-in-the-box effect
· image distortion so that a thick plus lens gives a pin-cushion effect and a thick minus lens gives a barrel effect.

·         A cylindrical lens has one plane surface and the other with curve surface. It has no power along its axis. Its power is 90 degrees to the axis and the lens forms a focal line parallel to its axis. It is used in Maddox rod for the measurement of phoria.
Maddox rod is used to measure distant phoria and Maddox wing for near phoria. Double Maddox rod can be used to measure cyclotorsion.

·         The circle of least confusion of the conoid of Sturm is located at the focal point of the spherical equivalent lens.
·         Duochrome test is a subjective test using the principle of chromatic aberration. It uses letters or numbers of the same colour usually black against different backgrounds: red and green. It is sensitive changes in refraction of 0.25D or less. To an emmetropic patient, letters of both the colours look equally sharp; while to a slightly myopic patient the red letters appear sharper and to a slightly hypermetropic patient the green letters look sharper.

·         High-order aberrations are ones that cannot be corrected by simple spherocylindrical systems, such as spectacles or contact lenses. They are caused by minute misalignments of the eye's optical components and include, in order of visual significance, spherical aberration, coma, higher-order astigmatism, and others. They can be detected with wavefront analysis performed with an instrument called aberometer. Theoretically, an ablation that removes aberrations increases visual contrast and the spatial detail of images seen by the eye.

·         Purkinje-Sanson images: The images are formed at 4 surfaces: the anterior (image 1) and posterior (image 2) corneal surfaces and the anterior (image 3) and posterior (image 4) lenticular surfaces. The first three images are erect and virtual whereas the last one is inverted and real. The first image is used for keratometry and images 3 and 4 are used for accommodation.
Hirschberg's test made use of the first captoptric image which is located on the anterior corneal surface for measuring ocular deviation. This image is also used for keratometry.

·         An image known as Sturm's conoid is produced by an astigmatic eye; such image can only be corrected with a spherocylindrical lens.

·         Unilateral nucleosclerosis and not posterior subcapsular cataract can lead to index myopia. Central serious retinopathy can cause hypermetropic shift.

·         SRK formula is used for IOL calculation. However, it is not accurate for eye less than 22mm or longer than 24.5mm. SRK II and SRK-T are more accurate than SRK. The SRK II uses adjusted A constant depending on the length of the eye. For eye with an axial length shorter than 21mm, Hoffer Q is preferable.

·         The Franklin design is a split bifocals in which a distance lens is mounted on a near lens. The problem of prismatic jump is related to the power of the lenses as well as the distance between the distance of the interface from its optical centre. Image jump can be reduced by moving the optical centres towards the junction of the two portions as in the executive glasses. Alternatively, a base up prism can be incorporated into the reading section.
Varifocal glasses has three sections: distance, intermediate (for VDU or working at arm length) and near (for reading). Varifocal or progressive lenses have no visible interface between the distance and near portions unlike bifocal or trifocal lenses. There is a power progression corridor (intermediate portion) which reduces the image jump seen in bifocal glasses; however on either side of the corridor aberration or astigmatism induced can become intolerable.

·         Soft contact lens with toric surface can be used to correct higher astigmatism.
Piggyback contact lens involves the use of two lenses, the soft contact lens provides the fitting surface for the rigid gas permeable lens.

·         Because of the prismatic effect of glasses with reading (base in in myopes and base out in hypermetropes), the myopes need less convergence and accommodation than when using the contact lenses, the converse is true for hypermetropes. Because of the additional accommodation and convergence required, contact lenses can cause eyestrain in presbyopic at an earlier age.

·         Corneal warpage refers to change in the corneal curvature associated with contact lens wear. Corneal oedema is absent. It is commoner with rigid gas permeable contact lens than soft contact lens. The result is reversible.

·         Giant papillary conjunctivitis is more common with soft than RGP lens. It is thought to be caused by deposits of denatured proteins. Ptosis is more common with RGP lens. It is thought to be related to the way the RGP lens is removed ie. temporal stretching of the lids combined with forceful lid closure.

·         Diabetic maculopathy is better detected with indirect ophthalmoscope than direct one.

·         The slit-lamp can be used to detect the presence of macular hole using the Watzke's sign.

·         The Hruby lens is a powerful plano-concave lens which gives a virtual, erect and diminished image. It is difficult to master and the image is too small for reliable photocoagulation. Coupling solution is not required as the lens does not come into contact with the eye. It is held with the concave side towards the patient. The image is formed within the eye.

·         The International Safety Classification of Lasers divides the lasers into 4 groups. Group 3 is subdivided into 3a and 3b. Class 3b and above is damaging to the eye and their powers are 5MW and above. All lasers used in  ophthalmology are classed as 3b and above. Safety goggles should always be worn by people in the vicinity.

·         Karl Himly (1806) was the first to employ the technique of oblique illumination examination.
·         Gullstrand invented the slit-lamp.
·         Babbage in 1848 invented the direct ophthalmoscope.
·         von Helmholtz in 1850 reinvented and popularised the ophthalmoscope.
·         Nagel in 1864 invented the indirect ophthalmoscopy.
·          

·         Two types of keratometers used in practice are Javal-Schiotz model and Bausch & Lomb model.

·         LASIK is laser-assisted in-situ keratomileusis. It is performed using ALK (automated lamellar keratectomy) machine and the excimer laser. This procedure is good for myopia of more than – 8D.

·         types of retinoscopes:
1.       Mirror retinoscopes, which may consist of a simple plane mirror or a combination of a plane mirror (on one end) and a concave mirror (on the other end). e.g., Pristley-Smith’s mirror.
2.       Self-illuminated streak retinoscope.

·         uses of red and green glasses or filters:
1.       Diplopia charting
2.       Worth’s four-dot test
3.       Malingering test
While testing, the red glass is kept in front of the right eye and the green glass is kept in front of the left eye.

·         Crown glass with refractive index 1.5223 is most commonly used for making spectacles.
·         +20 D is the power of the convex lens most commonly used in indirect ophthalmoscopy