- Phenoxybenzamine is an alkylating agent that forms a stable covalent bond with both a1- and a2-adrenergic receptors.This long-lasting receptor blockade cannot be overcome by competition with an agonist. Therefore, in contrast to the other drugs, blockade with phenoxybenzamine is not reversible, is referred to as nonequilibrium receptor blockade.
- In the peripheral nervous systems—that is, both branches of the autonomic nervous system, and the somatic nervous system—“the first nerve out of the CNS is always cholinergic and the ACh released from those nerves always activates the nicotinic subtype of cholinergic receptor.”
“all
the efferents in the peripheral nervous systems are cholinergic except postganglionic
sympathetics going to structures other than sweat glands.”
- Alice in Wonderland spin: Atropine poisoning
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